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Medtronic on Thursday announced that it is enrolling the first patients in its MIRACLE EF global clinical trial to evaluate the effectiveness of cardiac resynchronization therapy-pacemakers (CRT-Ps) in delaying the progression of heart failure in patients with mildly reduced heart pumping function.The study will be the first to evaluate CRT-P in what Medtronic calls a widely underserved patient group those who have a slightly reduced left ventricular ejection fraction (LVEF) but whose hearts work a bit more efficiently than heart failure patients who are currently approved for the device.The CRT-P devices used in MIRACLE EF are not approved by the FDA for the patient population being studied. Dr. Edward Schloss performed the first implant at The Christ Hospital's Lindner Research Center in Cincinnati, Ohio. The primary investigator for the site is Dr. Greg Egnaczyk. Previous studies have proven the real-world therapeutic benefits of CRT in treating mildly to severely symptomatic heart failure patients with moderately to severely reduced cardiac pumping capacity and electrical dyssynchrony, said Professor Cecilia Linde of Karolinska University Hospital in Stockholm, and worldwide principal investigator in the trial. Through this large global study we hope to further our research on the overall effectiveness of CRT-P by showing its benefit in treating patients with mild-to-moderate heart failure symptoms, but with milder impairment of heart pumping capacity than previously studied. Medtronic said that up to 2,300 patients at approximately 275 centers throughout the world including in the United States, Canada, Europe, Japan and developing markets will be enrolled in the trial. Patients will be followed for at least two years or until close of the study. The trial is expected to take four to five years to complete. We are hopeful that, when completed, MIRACLE EF will influence clinical practice guidelines regarding the use of advanced cardiac resynchronization devices and potentially lead to another expanded indication for Medtronic CRT devices, said David Steinhaus, M.D., vice president and general manager, Heart Failure, and medical director for the Cardiac <a href=http://www.s>louis vuitton</a> aclouisvuittono.com/]louis vuitton portefeuile Rhythm Disease Management business at Medtronic. We look forward to the positive implications these findings could have on heart failure patients whose disease is less pronounced, yet who still experience symptoms and need advanced therapeutic solutions.
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Name: | briancharlesgra  | E-Mail: | briancharlesgra sina.com | Homepage: | http://www.wholesaletopjerseys-online.com/ | Time: | 12/16/2012 at 6:46am (UTC) | Message: |
Gaza: Clinton works for truce 'in the days ahead'
Israeli air strikes shook the Gaza Strip and Palestinian rockets struck across the border as U.S. Secretary of State Hillary Clinton held talks in Jerusalem in the early hours of Wednesday, seeking a truce that can hold back Israel's ground troops.
Hamas, the Islamist movement controlling Gaza, and Egypt, whose new, Islamist government is trying to broker a truce, had floated hopes for a ceasefire by late Tuesday; but by the time Clinton met Israeli Prime Minister Benjamin Netanyahu it was clear there would be more argument, and more violence, first.
Hamas leaders in Cairo accused the Jewish state of failing to respond to proposals and said an announcement on holding fire would not come before daylight on Wednesday. Israel Radio quoted an Israeli official saying a truce was held up due to "a last-minute delay in the understandings between Hamas and Israel".
Who is Hamas? 5 questions about the Palestinian militant group.
An initial halt to attacks may, however, not see the sides stand their forces down from battle stations immediately; Clinton, who flies to Cairo to see Egyptian President Mohamed Mursi later on Wednesday, spoke of a deal "in the days ahead".
As she arrived in Israel after nightfall, Israel was stepping up its bombardment. Artillery shells and missiles fired from naval gunboats offshore slammed into the territory and air strikes came at a frequency of about one every 10 minutes.
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